Disease State: Acne
Acne is among the most common inflammatory dermatoses seen globally. It is well recognized that outcome measures used to assess the effectiveness of acne treatments are heterogeneous and inconsistently applied. There is a lack of both standardization and harmonization in their use. Since the early trials of the 1960s and 1970s, the focus has been on physician-assessed measures such as lesion counts and global severity scales. Instruments that assess impact of acne on patients have been utilized in more recent clinical trials. These have included generic, dermatology specific, and acne-specific quality of life scales. It is not currently known whether any of these measures is fit-for-purpose, in that they reproducibly measure what matters most to patients with acne, they are responsive to change, or they reflect those outcomes which patients instinctively use to self-assess how well a treatment is working.
The Acne Core Outcomes Research Network (ACORN) aims to establish a COS for interventional trials in acne. To date, consensus on the core domain set has been established and further work is underway to develop the core measures set. Instruments are in various stages of review or development, and these include measures for signs and symptoms, dark marks and scars, satisfaction with treatment, long term acne control, and health-related quality of life and satisfaction with appearance.
Satisfaction treatment received:
Key Project Team Members
C3 Methods Partner
The Centre for Appearance Research collaborates on the satisfaction with appearance domain
Leeds Beckett University, Leeds School of Social Sciences, UK collaborates on some of the PROMS
Alison Layton, firstname.lastname@example.org
Hopkins, Zachary H., MD; Thiboutot, Diane, MD; Homsi, Haya A, MD, MPH; Lourdes Maria, Perez Chada, MD; Barbieri, John, MD, MBA. Patient-reported outcome measures for health-related quality of life in acne vulgaris: a systematic review of measure development and measurement properties. In Progress
Layton AM, Thiboutot D, Tan J. Reviewing the global burden of acne: how could we improve care to reduce the burden? Br J Dermatol. 2021;184(2):219-225. https://pubmed.ncbi.nlm.nih.gov/32770673/
Tan J, Thiboutot D., Layton A., Miklas M. (2021) Developing a Core Outcome Set for Acne Clinical Trials: Towards Standardization and Harmonization. In: Suh D.H. (eds) Acne. Updates in Clinical Dermatology. Springer
Smith H, Layton AM, Thiboutot D, Smith A, Whitehouse H, Ghumra W, Verma M, Tan J, Jones G, Gilliland K, Patel M, Otchere E, Eady A. Identifying the Impacts of Acne and the Use of Questionnaires to Detect These Impacts: A Systematic Literature Review. Am J Clin Dermatol. 2021;22(2):159-171. https://pubmed.ncbi.nlm.nih.gov/33175359/
van Zuuren EJ, Arents BWM, Miklas M, Schoones JW, Tan J. Identifying and appraising patient-reported outcome measures on treatment satisfaction in acne: a systematic review. Br J Dermatol. 2021;185(1):36-51. https://pubmed.ncbi.nlm.nih.gov/33176002/
van Zuuren EJ, Arents BWM, Vermeulen S, Tan J. Harmonizing Measurement of Satisfaction With Acne Scar Treatments: Can We All Sing the Same Tune? Dermatol Surg. 2021;47(9):1323-1324. https://pubmed.ncbi.nlm.nih.gov/34148997/
Updated on May 1, 2022