Disease State: Congenital Melanocytic Naevi
Presence of large congenital melanocytic naevi (CMN) is associated with psychosocial burden on patients and parents because of its remarkable appearance and additional care it may require. Large CMN also pose an increased risk of malignant melanoma or neurocutaneous melanosis. There is a lack of international consensus on which domains are important to measure in relation to treatment, making it difficult to compare treatemnt options and guide treatment standards for CMN.
To develop a COS for clinical care and interventional treatments (laser, excision, curettage, watchful waiting) for large CMN (≥1.5cm on face or ≥ 10cm elsewhere).
Key Project Team Members
Claire van Eijsden
Chantal M.A.M. van der Horst
Marjolein van Kessel
C3 Methods Partner
Anne Fledderus (email@example.com)
Fledderus AC, Franke CJJ, Eggen CAM, van Etten-Jamaludin FS, van der Horst CMAM, Brinkmann SJH, Spuls PI. Outcomes and measurement instruments used in congenital melanocytic naevi research: A systematic review. J Plast Reconstr Aesthet Surg. 2020;73(4):703-715.
Oei W, Fledderus AC, Korfage I, Eggen CAM, van der Horst CMAM, Spuls PI, Brinkmann SJH, Wolkerstorfer A, van Kessel M, Pasmans S. Protocol for the development of core set of domains of the core outcome set for patients with congenital melanocytic naevi (OCOMEN project). J Eur Acad Dermatol Venereol. 2020;34(2):267-273.
Oei W, Fledderus AC, Spuls PI, Eggen CAM, Kottner J, van der Horst CMAM, Wolkerstorfer A, van Kessel MS, Krengel S, Etchevers HC, Korfage IJ, Pasmans SGM. Development of an international core domain set for medium, large and giant congenital melanocytic naevi as a first step towards a core outcome set for clinical practice and research. Br J Dermatol. 2021;185(2):371-379.
Fledderus AC, Pasmans SGMA, Wolkerstorfer A, Oei W, Etchevers HC, van Kessel MS, van der Horst CMAM, Spuls PI. Domains and outcomes of the core outcome set of congenital melanocytic naevi for clinical practice and research (the OCOMEN project): part 2. Br J Dermatol. 2021;185(5):970-977.
PHD thesis: Fledderus (2021) Outcomes for Congenital Melanocytic Naevi ISBN: 978-94-93197-82-4, Universiteit van Amsterdam
Updated on Date: June 22, 2022