Disease State: Atopic eczema / Atopic dermatitis / Eczema
HOME is a global initiative involving patients, healthcare professionals, journal editors, regulatory authorities and the pharmaceutical industry to establish a consensus-agreed core outcome set for eczema (homeforeczema.org).
Despite a high burden of atopic eczema, evidence-based clinical care and decision making is limited by the use of multiple, unvalidated outcome measures. A systematic review (Charman et al. 2003), showed that only 27% of the 93 included trials utilize a published severity scale, with the remainder using modified versions of published scales or un-named scales with no data on validity or reliability. Another systematic review (Schmitt et al. 2007) showed that most named outcome measurements for eczema have not been tested sufficiently and have inadequate performances related to validity, reliability, or ease of use.
HOME was founded in 2008 by Professors Hywel Williams and Jochen Schmitt to bring together the eczema research community to standardise outcome measures by agreeing a core outcome set to be included in all eczema clinical trials.
Scope of the intended COS:
- Study types: Clinical Trials. A core set for clinical practice and use in registries is also being developed alongside the clinical trials core outcome set
- Region: Global
To develop a consensus-based core outcome set (COS) for clinical trials and a clinical practice set.
Consensus on core outcome domains and instruments has been achieved. The focus of HOME is now on implementation of the core set.
© 2022 Williams et al. https://doi.org/10.1016/j.jaci.2022.03.017
More information on the HOME Core outcome domains and instruments
HOME Executive Members
Eric Simpson, Christian Apfelbacher, Jochen Schmitt, Hywel Williams, Phyllis Spuls, Kim Thomas, Norito Katoh, Yael Leshem, Louise Gerbens, Laura Howells
C3 Methods Partner
- HOME Roadmap
Home developed the methodological Roadmap for development of a core outcome set and has followed this roadmap (along with other guidance from COMET and COSMIN).
Schmitt J, Apfelbacher C, Spuls PI, Thomas KS, Simpson EL, Furue M, Chalmers J, Williams HC. The Harmonising Outcomes for Eczema (HOME) roadmap: A methodological framework to develop core sets of outcome measurements in dermatology. J Invest Dermatol. 2015;135(1):24-30. https://pubmed.ncbi.nlm.nih.gov/25186228/
- HOME Core Set
A summary paper describing the HOME core outcome set from inception to completion
Williams HC, Schmitt J, Thomas KS, Spuls PI, Simpson EL, Apfelbacher CJ, Chalmers JR, Furue M, Katoh N, Gerbens LA, Leshem YA, Howells L, Singh JA, Boers M; HOME Initiative. The HOME Core outcome set for clinical trials of atopic dermatitis. J Allergy Clin Immunol. 2022 Jun;149(6):1899-191 https://www.jacionline.org/article/S0091-6749(22)00389-X/fulltext
Updated on Date: June 23, 2022